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49ers quarterback Jimmy Garoppolo suffers high-ankle sprain, could miss next week vs. Giants

  | USA TODAY

The injuries keep piling up for the San Francisco 49ers.

Quarterback Jimmy Garoppolo could miss next week’s game against the New York Giants after leaving Sunday’s 31-13 win against the New York Jets, coach Kyle Shanahan said.

Garoppolo appeared to sustain the injury on a first-quarter sack from Jets defensive lineman Quinnen Williams, but he remained in the game and was attended to by trainers. In the second half, however, Nick Mullens took over at quarterback with the 49ers holding a 21-3 lead.

Garoppolo completed 14 of 16 passes for 131 yards and two touchdowns before leaving.

The 49ers also lost starting running back Raheem Mostert to a knee injury.

Earlier in the day, defensive end Nick Bosa and defensive lineman Solomon Thomas were both ruled out after knee injuries. Bosa is feared to have suffered a torn anterior cruciate ligament, Shanahan said.

San Francisco was already without cornerback Richard Sherman, who had been placed on injured reserve with a calf injury, and tight end George Kittle, who was ruled out with a knee injury he sustained in Week 1.

Follow Michael Middlehurst-Schwartz on Twitter @MikeMSchwartz.

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