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Detroit Lions at Green Bay Packers odds, picks and best bets

The Green Bay Packers (1-0) host the NFC North-rival Detroit Lions (0-1) in Week 2 at Lambeau Field. Kickoff will be at 1 p.m. ET. Below, we preview the Lions-Packers betting odds and lines and make our NFL picks and best bets.

Aaron Rodgers erupted in Green Bay’s 43-34 Week 1 win over the Minnesota Vikings and Detroit ripped defeat out of the jaws of victory in its 27-23 loss to the Chicago Bears.

Lions at Packers betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 1 p.m. ET. 

  • Money line: Lions +225 (Bet $100, win $225) | Packers -278 (bet $278, win $100)
  • Against the spread/ATS: Lions +6 (-110) | Packers -6 (-110)
  • Over/Under: 49.5 (O: -110, U: -110)

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Lions at Packers game notes

  • The Lions are 6-0 ATS in their last six games against the Packers and 4-1 ATS in their last five meetings in Green Bay.
  • Detroit blew a three-score lead heading into the fourth quarter of its Week 1 loss to Chicago.
  • Rodgers was surgical against the Vikings in Week 1: He had the second-highest QBR in Week 1 (92.9) and the fourth-highest completion percentage above expectation, according to NFL’s Next Gen stats.
  • Green Bay’s run game complemented Rodgers nicely. The Packers averaged 4.9 yards per rushing attempt and added one touchdown in Week 1.
  • Since 2017, the Packers have covered the spread in only 42% (8-11 ATS) of division games.

Lions at Packers key injuries

Lions

  • CB Desmond Trufant (hamstring) out
  • WR Kenny Golladay (hamstring) out

Packers

  • DT Kenny Clark (groin) out

Lions at Packers: Odds, betting lines, picks and prediction

Prediction

Packers 24, Lions 20

Money line (?)

PASS ON THE MONEY LINE because of Detroit’s troubling injury report.

The Packers (-278) and Rodgers put it on the Vikings in Week 1, as Green Bay feasted against a weak Minnesota secondary. WR Davante Adams went off for 14 catches, 156 yards and two receiving TDs.

The Lions’ (+225) have their own concerns in the secondary. Trufant is out, Darryl Roberts is listed as questionable and rookie CB Jeff Okudah will be making his first start this week and will be assigned to Adams. Not an easy first week of work.

Also, there are a couple of injuries on Detroit’s offensive line so Green Bay edge rushers Preston Smith and Za’Darius Smith may be in Matthew Stafford‘s face all afternoon.

Against the spread (?)

The Lions +6 (-110) have played the Packers -6 (-110) tough over recent seasons—winning four of their past six meetings and covering the spread in all six. Detroit is getting some value because of a trademark Lions fourth-quarter collapse in Week 1 and Green Bay bullied a Vikings team that’s in for a down year.

These teams know each other and both QBs are healthy. No home crowd plus no weather takes away most of the Lambeau edge. TAKE LIONS +6 (-110).

Over/Under (?)

The Lions and Packers have gone Under the total in three straight meetings and 96% of the cash wagered is on Over, according to Pregame.com. I’d rather be on the side of the house, especially if it’s as lopsided.

Green Bay will be without Clark and Detroit has a good backfield featuring an Adrian Peterson who looked like his old self in Week 1. The Lions will try to keep Rodgers off the field to protect their banged-up secondary and play a little keep away.

I LEAN UNDER 49.5 (-110).

A “lean” is not necessarily a bet. Proceed at your own caution.

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